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The Partners of the project: Geographical Location (EU)

The consortium counts 11 partners coming from 8 different European countries. From 01/01/2007 2 new partners from Asia will join the consortium.

Click on a city to view information about the partner or go directly to the list of partners.

partners of the Epistem project VIB; Ghent, Belgium RUNMC; Nijmegen, Netherlands UTV-DEMBS; Rome, Italy UNIL; Lausanne, Switzerland KCL; London, United Kingdom KI; Stockholm, Sweden UNIFRA; Frankfurt, Germany UniMI; Milano, Italy IOM; Viagrande; Italy INSERM; Nice, France GeneSpin; Milano, Italy
 1. VIB; Ghent (B)
 2. RUNMC; Nijmegen (NL)
 3. UTV-DEMBS; Rome (IT)
 4. UNIL; Lausanne (SUI)
 5. KCL; London (UK)
 6. KI; Stockholm (SE)
 7. UNIFRA; Frankfurt (D)
 8. UniMI; Milano (IT)
 9. I.O.M; Viagrande (IT)
10. INSERM; Nice (F)
11. GeneSpin; Milano (IT)
 12. CMU; Chiang Mai (TH)
 13. SJTU; Shanghai (CN)
 asian partners of the Epistem project CMU; Chiang Mai; Thailand SJTU; Shanghai; China

The Partners of the project: a list

1. VIB/UGent

logo VIB
Flanders Interuniversity Institute for Biotechnology / University of Ghent

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2. RUNMC

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Radboud University Nijmegen

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3. UTV-DEMBS

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Universita Degli Studi di Roma Tor Vergata

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4. UNIL

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University of Lausanne

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5. KCL

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King's College London

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6. KI

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Karolinska Institutet

  • Acronym:  KI
  • City:  Stockholm
  • Country:  Sweden (SE)
  • Website: 
  • Research group:
    • Klas Wiman send mail
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7. UNIFRA

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J.W. Goethe-Universitat Frankfurt am main

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8. UniMI

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Universita degli Studi di Milano

  • Acronym:  UniMI
  • City:  Milano
  • Country:  Italy (IT)
  • Website: 
  • Research group:
    • Roberto Mantovani send mail
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9. I.O.M.

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Instituto Oncologico del Mediterraneo

  • Acronym:  I.O.M.
  • City:  Viagrande
  • Country:  Italy (IT)
  • Website: 
  • Research group:
    • Max Gulisano send mail
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10. INSERM

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Institut National de la Sante et de la Recherche Medicale

  • Acronym:  INSERM
  • City:  Nice
  • Country:  France (F)
  • Website: 
  • Research groups:
    • Daniel Aberdam send mail
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P10. Group of Daniel Aberdam

Their research interest focuses on the function of the various p63 isoforms and to the identification of their target genes during ectodermal commitment and epidermal differentiation. They recently demonstrated that, under experimental culture conditions, murine embryonic stem cells can differentiate into keratinocytes and even reconstitute in vitro a functional epidermis. Their laboratory has further developed a unique cellular model that recapitulates embryonic development of epidermis and skin appendages. They derived and established ectodermal precursor cell lines from murine embryonic stem (ES) cells and demonstrated that exogenous expression of TAp63 is sufficient to convert the ES-derived ectodermal cells into keratinocytes. This partner has expertise in transcriptome analysis approaches coupled with functional genomic techniques (siRNA, overexpression, ChIP). In addition, they have in house technology to evaluate the potential involvement of the identified genes on epidermal and skin appendage commitments in vitro and in vivo after grafting of the resulting cells onto syngenic mice.

relevant references

Aberdam D. (2004) Derivation of keratinocyte progenitor cells and skin formation from embryonic stem cells. Int J Dev Biol. 48, 203-206.
Coraux C, Hilmi C, Rouleau M, Spadafora A, Hinnrasky J, Ortonne JP, Dani C, Aberdam D. (2003) Reconstituted skin from murine embryonic stem cells. Curr Biol. 13, 849-53
Virolle T, Coraux C, Ferrigno O, Cailleteau L, Ortonne JP, Pognonec P, Aberdam D. (2002) Binding of USF to a non-canonical E-box following stress results in a cell-specific derepression of the lama3 gene. Nucleic Acids Res. 30, 1789-98.
Virolle T., Djabari Z., Ortonne J.P. and Aberdam D. (2000) DNA conformation driven by AP-1 triggers cell-specific expression via a strong epithelial enhancer. Embo Reports 1, 328-333.

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11. GeneSpin

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GeneSpin

  • Acronym:  GeneSpin
  • City:  Milano
  • Country:  Italy (IT)
  • Website: 
  • Research group:
    • Luca Lorenzi send mail
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12. CMU

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Chiang Mai University

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13. SJTU

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Shanghai Jiaotong University

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