• 12.00: Registration opens
• 13.45: Welcome

Session 1: Genetic defects in epidermal dysfunction

• 14.00: Session 1a - Chair: Nik Kantaputra
  • John McGrath (30')
    "Molecular basis of non-p63 ectodermal dysplasia syndromes"
  • Hans van Bokhoven (30')
    "Genotype-phenotype correlation for p63-associated ectodermal dysplasia syndromes"
  • Jo Huiqing Zhou (15')
    "Amino-terminal truncation mutations in the ΔNp63 protein result in Rapp-Hodgkin/Hay-Wells like ectodermal dysplasia syndromes"
  • Luisa Guerrini (15')
    "The Y192C and K193/4E natural p63 mutation are phospho mimetic mutations that abolish ubiquitin and SUMO-mediated p63 degradation"
• 15.30: Coffee break
• 16.00: Session 1b - Chair: John McGrath
  • Nik Kantaputra (30')
    "Craniofacial Manifestations of p63-associated ectodermal dysplasia syndromes"
  • Caterina Missero (30')
    "Signaling pathways downstream of p63 in the AEC syndrome"
  • Giustina Ferone (15')
    "Generation of a mouse model for the AEC syndrome"
  • Stefania Gonfloni (15')
    "Female fertility after chemotherapy can TAp63 offer a way to protect oocytes from apoptosis?"
• 17.30: Key-Note Speaker - Frank McKeon
  "Of Female Superiority and Stemness: The Two Sides of p63"
• 18.30: Concert of Octocelli
• 19.30: Reception

Session 2: Molecular signaling in epidermal differentiation

• 9.00: Session 2a - Chair: Gian Paolo Dotto
• Michael Dixon (30')
  "The role of IRF6 in epidermal and oral epithelial development"
• Wim Declercq (30')
  "Role of caspase-14 in epidermal differentiation"
• Jill Dixon (15')
  "The interaction between p63 and Irf6 during palate development"
• 10.15: Coffee Break
• 11.45: Session 2b - Chair: Gerry Melino
• Jingde Zhu (30')
  "Fundamental and translational cancer epigenetics(-omics) from the DNA methylation perspective"
• Roberto Mantovani (30')
  "Shedding light on the network of p63 targets in keratinocytes"
• Eleonora Candi (30')
  "Role of the E3 ubiquitin ligase Itch in epidermis"
• Charlotte Ruptier (15')
  "Regulation of ΔNp63 expression"
• 12.30: Lunch
• 13.15: Guided City Tour
• 15.30: Session 2c - Chair: Wim Declercq
• Gerry Melino (30')
  "Itch-dependent degradation of p63 in Ectodermal Dysplasia"
• Gian Paolo Dotto (30')
  "Notch signaling : a key node in the control system network of keratinocyte stem cell potential and carcinogenesis"
• Manolis Pasparakis
  "IKK/NF-kappaB signalling in epidermal homeostasis"
• 17.00: Coffee break
• 17.30: Session 2d (3x30' and 2x15')
• Volker Doetsch (30')
  "Structural investigation of oligomerization domains in the p53 protein family"
• Klas Wiman (30')
  "Mutant p63 targeting by small molecules"
• Martijn Huynen (30')
  "Integration of genomics data for reliable and specific protein function prediction"
• Viola Calabrò (15')
  "Dlx3 and Raf1 cooperate to induce phosphorylation-dependent p63 protein degradation"
• Laurent Le Cam (15')
  "Roles of E4F1-mediated regulation of p63 in epidermal homeostasis"
• 19.30: Poster session with reception

Session 3: Stem Cell Research

• 8.45: Session 3a - Chair: Roberto Mantovani
• Daniel Aberdam (30')
  "Role of p63 isoforms in embryonic epidermal fate. Relevance to ectodermal dysplasia syndromes"
• Cédric Blanpain (30')
  "Regulating the function of skin stem cells"
• Salvador Aznar Benitah (15')
  "Balancing epidermal stem cells and transit amplifying cells by Rac1 and Myc"
• Michèle Martin (15')
  "FGF2 signalling is critical for DNA repair in human epidermal stem cells"
• Carien Niessen (15')
  "Insulin and IGF-1 are essential components of the interfollicular progenitor cell niche"
• 10.30: Coffee Break
• 11.00: Session 3b (1x30' and 2x15')
• George Cotsarelis
  "Hair follicle stem cells and skin regeneration"
• Vladimir Botchkarev
  "Bone morphogenetic protein signaling in the control of skin development, hair growth and tumorigenesis"
• 12.00: Key-Note Speaker - Catherine Verfaillie
  "Mechanisms underlying increased potency of somatic (stem) cells"
• 13.00: End